The Lilywhites enjoyed a romp in the sun at Irongate with Garner, Mousinho, Byrom and an own goal making it a super six performance.
North End were ahead inside a minute when Joe Garner put pressure on lifelong North End fan Ryan Thompson, who put into his own net from eight yards out.
Garner himself doubled the lead almost on the stroke of half-time as he converted Chris Beardsley’s right wing cross from ten yards out, off the advancing Lee Dovey in the brig goal.
Joel Byrom grabbed his second goal in as many games just after the interval, finishing off some good play from Jeffrey Monakana to make three.
Garner grabbed a second set up by Mousinho and then the combination was reversed as the No.21 was set up by the frontman for the fifth.
Bailey Wright made it six in the 88th minute with a header from Lee Holmes' corner to add further gloss to a comfortable win.
Manager Simon Grayson had started with eight of those who came on as 60 minute substitutes at Chorley 24 hours before, only Paul Huntington and Scott Laird starting again, with Jeffrey Monakana starting his first game of pre-season.
The game began with a flash; Johnstone looped a shot over the bar for Brig after only 20 seconds, but from the goalkick North End broke and John Mousinho won and took a quick free kick that saw Joe Garner in on goal. The No.14 couldn’t get the ball under control, but defender Ryan Thompson, a Leyland lad, diverted the ball past Dovey into the bottom left hand corner.
Monakana looked lively on the right hand side in his first run out of the campaign and the former Arsenal man had a shot blocked in the 13th minute from Byrom’s left wing cross deep to the back right corner of the box.
At the mid-point in the half Joel Byrom was given a chance to repeat his effort at Victory Park, when North End were awarded a free kick 28 yards out. Again he curled the ball up and over the wall, but it crashed into the cross bar and over.
A minute later and Monakana again showed his abaility with a great run down the right; he cut inside and curled an effort that Dovey tipped round the post for a corner.
Just after the half hour mark Brig made a change with Bell on up front and with his first touch of the game he almost levelled matters, shooting from the right hand corner of the box tipped over by Thorsten Stuckmann.
Monakana was again on the right with six minutes left of the first period. He collected the ball from Mousinho and drove a shot across the face of goal, but just the wrong side of the left hand post.
However, North End deservedly doubled their advantage on the stroke of half-time. Joe Garner finished off a good move by PNE; Ryan Croasdale winning the ball in the middle of the park, feeding Chris Beardsley, who rolled the ball across to Garner, who slid home off the keeper from ten yards out after stepping inside past a defender.
It was 3-0 just five minutes into the second period. More good work by Jeffrey Monakana on the right as he beat his full back and pulled the ball back cleverly to the back post where Joel Byrom made it two in two with a strong right-footed finish past Dovey.
Monakana almost made it another assist in the 53rd minute with a well-weight cross for Garner, but the frontman’s powerful header was inches past the left hand post.
The wing man continued to be a threat and nearly went from goal provider to goalscorer on 56 minutes when he thrust his way right through the heart of the Brig defence, but dragged his shot just past the right hand post from the edge of the Irongate box.
The home goal was being peppered by North End and on 58 minutes Chris Marlow, another PNE fan in the Bamber Bridge ranks, cleared Jack King's powered effort off the line and from the clearance the Lilywhites should have been awarded a penalty when Neil Reynolds, the player assistant manager, handled the ball away from the advancing Bailey Wright, however, referee Graham Salisbury was unsighted.
Joe Garner bundled home North End's fourth of the evening after excellent play by North End skipper John Mousinho, who powered down the right hand channel. He then got to the byline and pulled it back for Garner, whose initial shot was parried by Dovey, but he managed to ensure it ended up in the net despite pressure from a Brig defender.
A minute later and the same combination brought a fifth, this time in reverse, Garner pulling the ball back from the left touchline for 'Mous' to fire home from around the penalty spot.
In the aftermath North End made six changes, both the latest goalscorers amongst those replaced.
John Welsh then found the bar as his nemesis with 74 minutes on the clock, firing a shot, at the second attempt, from 20 yards that came flashing back off the woodwork.
Bailey Wright added a since with 90 seconds left, flicking home Lee Holmes' right wing corner just as the sun was setting in the corner of the Irongate stands and the final whistle followed shortly after,
: Stuckmann (Rudd, 64), Clarke (King, 46), Laird (Buchanan, 46), Mousinho (Welsh, 64), Huntington (Wright, 46), B Davies (Cansdell-Sherriff, 46), Monakana (Holmes, 64), Byrom, Garner (Hume, 64), Beardsley (Cummins, 64), Croasdale (Wroe, 64).PNE line-up
: Dovey, Thompson (Doughty, 46), Marlow, Bonaminio, Lawlor, Kay, Waddecar, Mahoney (Evans, 74), Johnstone (Bell, 32 (Buchan, 65)), Wilkins, Reid (Reynolds, 46). Subs not used: Hunt, Coates.Bamber Bridge line-up
: Mr Graham SalisburyReferee