PNE boss Simon Grayson told PNEPlayerHD that North End's decision making cost them any chance of picking up points this afternoon.
North End responded well, most notably through Callum Robinson who struck the post from long range mid-way through the first-half.
Wednesday were reduced to ten men when goalscorer Forestieri saw red for an incident off the ball which saw the momentum switch in North End's favour. However, against the run of play, the hosts doubled their advantage through Steven Fletcher's converted spot-kick.
Eoin Doyle halved the deficit, but it wasn't enough with Wednesday claiming victory.
"I'm extremely disappointed with how we've played at times and obviously how the game ended," said Grayson.
"The decision making today was dreadful from every individual on that pitch today - regardless if we got a point out of the game, I would have mentioned that to the players regardless of the result.
"From the first whistle, players were making poor decisions even against ten men, we made shocking decisons - instead of driving into the box with ten men we decided to cross it and you've got players for them who want to head the ball.
"Ultimately we weren't clever enough up to the incident which led to the sending off."
The incident in question, which saw both Jermaine Beckford and Eoin Doyle being red carded was something the manager admitted he had never seen in 30 years of professional football.
"I have never seen anything like it in my career," said Grayson after the final whistle. "Two teammates being sent off for being involved in an incident together.
"It's ridiculous - the timing of it, the incident itself is totally unacceptable. At that moment we were in the game - it was 11 v ten, at 2-1 and a great opportunity of getting something from the game.
"We've suffered bad days in terms of defeats but today's a difficult day because we should have got something out of that game.
"We were too slow and too pedestrian, we were too open so that was a disappointing part of our game today. We still had some decent chances to win the game but all factors contribute to an incident - I can't use a word to describe it that's suitable for television.
"Their crowd were obviously not too happy with the sending off but Forestieri's shoved Ben Pearson in the face so that's stupid on their part - a lot of stupid things have happened on the field today which I'm not very impressed with."
The manager continued: "I'm bubbling - I will assess the situation - regardless if we appeal it's an absolutely ridiculous decision from both of our players and they will both be reprimanded regardless if we think we can get away with it because ultimately it's cost us the game.
"11 against ten we could have got something out of the game, but the pair of them have cost us - the supporters who have travelled over here. It's not been a cheap day, I think tickets were £33 which was ridiculous as well so for the supporters having to pay for that for them to be let down by a couple of stupid decisions by the two players."
To hear more from an honest Simon Grayson after the game, head to PNEPlayerHD here now.