Tuesday night's two Lancashire sides have met four times before in cup competitions in the last 11 years.
Two previous ones have been in the League Cup and back in 2009 the Lilywhites put the Shrimps to the sword at Deepdale.
And it was four headed goals that helped North End secure a place in the Carling Cup second round after a comfortable win over their north Lancs opponents.
Mark Duffy missed a penalty for the League Two side at 0-0 after goalkeeper Andy Lonergan had been adjudged to have fouled Ian Craney by referee Craig Pawson.
Chris Brown opened the scoring on 33 minutes after he got on the end of a cross from the right by Michael Hart and shortly before the break Steve Elliott rose highest to head home a cross from Ross Wallace.
Alan Irvine's men continued to dominate proceedings and they claimed a third in the 57th minute when another fine cross from Wallace was headed home by Barry Nicholson.
Twelve minutes later, the lead was extended to four when substitute centre half Neal Trotman made an immediate impact by powering home a header from Nicholson's left-wing cross.
While Neil Mellor hit the fifth in injury time, rifling home a cross from Chris Sedgwick before Michael Twiss' fired a low effort consolation for the visitors in front of almost 5,500 in PR1.