Both Tuesday night's two teams could make changes for the Carabao Cup first round tie at Deepdale.
North End boss Alex Neil will be without long-term absentees Billy Bodin and Sean Maguire, but could well give chances to other members of his squad.
Paul Gallagher, Graham Burke and Brandon Barker all came off the bench on Saturday and the latter two, along with Lukas Nmecha, could be in with a chance of making their competitive home debuts.
There are no other injury concerns for the manager, who could also choose to hand full competitive debuts to Jordan Storey and Ryan Ledson, if he decides to change up from the side that has only seen one change to its starting XI in the first two league games.
Meanwhile, Jim Bentley has also indicated he is set to make changes for the tie, with his side still waiting for their goal of the season after clashes with Crewe Alexandra and Exeter City.
Rhys Oates came off the bench at the weekend, after starting the first game, and he could return to the side, whilst Jason Oswell could get his chance in attack.
Luke Conlan is another player who could get an opportunity, with the Shrimps boss having choices, should be wish to make alterations after the clash with the Grecians at the weekend.