Manager Ryan Lowe has confirmed Emil Riis will be seeing a specialist in the coming days to discover the severity of his knee injury.
The Danish forward limped off in Monday’s victory over Stoke City after 23 minutes, following a collision with the advertising boards on the perimeter of the pitch.
Ryan told iFollow PNE: “Emil’s in a brace at the moment, but he’s got to see a specialist.
“Until we get penciled in to see the specialist then we can’t make too many noises about what it is.
“We roughly know what it is but not how long it’s going to be, it’s not fair on him or on us to say something that’s not right.
“So once he’s had that specialist’s opinion then we’ll know a little bit more. The likelihood of losing him for a bit is very high, but until we get the full results we can’t really pass comment on how long it’ll be.
“It’s disappointing to lose someone by hitting the advertising boards in a dip off the pitch. If it’s a tackle you can take it or if it’s something in a game, but the way he’s fell and the way he’s landed is obviously awkward with him hitting the advertising boards.
“That’s something you shouldn’t be injured by. Ultimately we have to just get on with what it is and what will be will be.”
Elsewhere, Robbie Brady and Troy Parrott are both now back in training, with the latter having recently been given the all-clear by parent club Tottenham Hotspur.
The Irish duo’s progress will be monitored on Thursday and Friday to determine whether or not Saturday’s Emirates FA Cup third round tie against Huddersfield Town will come too soon.
Speaking about the competition, Ryan said: “I love it. FA Cup weekends are magical moments and it’s something that we want to make magical by getting into the fourth round.
“We know it’s going to be tough. There’s a tough team standing in our way who have had some good form of late.
“They obviously beat us last time round. We want to try and put that right of course, but we’re really looking forward to an exciting weekend of FA Cup action.”
As mentioned by Ryan, the Terriers came out on top the last time the two came head to head, leaving Deepdale with three points courtesy of a 2-1 Boxing Day victory.
PNE have, however, beaten the side from West Yorkshire twice away from home this season, once in the Carabao Cup and then in the Championship.
“It’s a good test,” the boss added. “There’s always challenges along the way. They’re going to pose a different challenge with whatever team or squad they bring, the same as us.
“It’s good knowing now what they did to us last time, can we make sure that doesn’t happen again?
“We’ve got to make sure that we can do the right things because I thought there were some moments in the game where we were very good and some moments where we were alright.
“But you know next time when you play them teams that you’ve got to make sure you’re better than you were last time round and that’s certainly going to be the case.”