Ryan Lowe confirmed Ali McCann, Ben Whiteman and Brad Potts are unlikely to feature for the remainder of the season.
Midfielder McCann has missed the previous two outings with a thigh problem, while Whiteman and Potts have been longer-term absentees.
North End’s No.4 picked up an ankle injury against Stoke City in March and Pottsy suffered another hamstring setback a week later against Plymouth Argyle.
Providing an update ahead of Saturday’s QPR fixture, Ryan said: “Whitey’s been given a little bit of time off just to be away from it. He’s worked ever so hard to try and push himself.
“The range in his ankle is not as good as we’d have liked it to be. It’s progressing really well, but he’s not quite ready.
“In terms of his fitness he’s always a fit lad, but he hasn’t been able to do much because of his ankle.
“Pottsy’s on the grass and he’s out doing stuff with a ball. There’s a risk element that we put him in like we did at Plymouth and he goes off again. We don’t want that so we’ll probably just leave him.
“Ali’s making good progress. There’s probably only ten sessions left I think until the end of the season so we won’t be risking them and bringing them back any time soon.”
On a more positive note, though, Liam Millar is expected to be available again at Loftus Road, having returned to training on Thursday.
Ryan Ledson featured for the first time since mid-March against Southampton during the week, and he could be in contention to feature at MATRADE Loftus Road.
Skipper Alan Browne may also be in line to return to the starting XI.
Ryan said: “Browney has had some delayed onset muscle soreness, which he’s had for a while. Obviously the physios have been holding him back because what we didn’t want him to do is really rupture or tear his calf muscles, with the pain he’s been going through.
“With a bit more rest and 20 minutes against Southampton, a recovery and rest day yesterday, he’s trained a bit today and he’ll continue to do that tomorrow.”
It’ll certainly be a boost for North End to get a few more players back available as they head into the final three matches of the campaign.
Heading to Loftus Road on Saturday, the Lilywhites are facing a Queens Park Rangers side still with work to do to retain their status as a Championship side, whereas PNE have ambitions of their own to finish the season well.
Ryan said: “The message is we’ve got three important games to play for and try and get as many points as we possibly can.
“We’re on a progression path of where we want to try and get to. We’ve got 63 points with three games to go from now.
“It’s important that we go and collect a few more points. I know we’ve got good teams and teams fighting for different things, but we’ve got to relish them opportunities. I’ve said that to the group.
“I want them to give everything they’ve got against a team that are fighting to get points and showcase how good they’ve been over the course of the season.”
